(Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

Base Information

• Chemical Name: (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester
• CAS No.: 186528-45-0
• Molecular Formula: C₂₈H₃₅NO₅S
• Molecular Weight: 497.656

Synonyms:(Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

Chemical Property of (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

There total 3 articles about (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + (Z)-7-[(1S,2R,3R,4R)-3-(4-Iodo-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester (557792-42-4) → (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester (186528-45-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 60 ℃;

DOI:10.1021/jm020517g

Reference yield:

p-Iodobenzenesulfonyl chloride (98-61-3) → (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester (186528-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: Pd(PPh₃)4; K₂CO₃ / toluene / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In dichloromethane; toluene; 2: Suzuki reaction;

DOI:10.1021/jm020517g

Reference yield:

(1S,2R,3R,4R)-(5Z)-7-(3-amino-bicyclo[2.2.1]hept-2-yl)hept-5-enoic acid methyl ester → (Z)-7-[(1S,2R,3R,4R)-3-(4'-Methoxy-biphenyl-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester (186528-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: Pd(PPh₃)4; K₂CO₃ / toluene / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In dichloromethane; toluene; 2: Suzuki reaction;

DOI:10.1021/jm020517g

upstream raw materials:

4-methoxyphenylboronic acid

(Z)-7-[(1S,2R,3R,4R)-3-(4-Iodo-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

p-Iodobenzenesulfonyl chloride

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