trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide

Base Information

• Chemical Name: trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide
• CAS No.: 109287-34-5
• Molecular Formula: C₉H₈N₂O₄
• Molecular Weight: 208.174
• Mol file: 109287-34-5.mol

Synonyms:trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide

Chemical Property of trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide

There total 2 articles about trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-nitrobenzaldehdye (555-16-8) + Chloroacetamide (79-07-2) → trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide (109287-34-5)

Guidance literature:

With methanol; sodium methylate; at 20 ℃; for 5h; diastereoselective reaction;

DOI:10.1134/S1070363217120088

Reference yield:

→ trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide (109287-34-5)

Guidance literature:

With ethanol; ammonia;

Reference yield: 87.0%

trans-3-(4-itrophenyl)-2,3-epoxypropionic acid amide (109287-34-5) + acetone (67-64-1) → syn-5-(α-chloro-4-nitrobenzyl)-2,2-dimethyl-1,3-oxazolidin-4-one

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 24h; diastereoselective reaction;

DOI:10.1134/S1070363217120088

upstream raw materials:

4-nitrobenzaldehdye

Chloroacetamide

Downstream raw materials:

2-hydroxy-3-(4-nitrophenyl)acrylic acid