2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester
• CAS No.: 1246190-34-0
• Molecular Formula: C₁₉H₂₅NO₄
• Molecular Weight: 331.412
• Mol file: 1246190-34-0.mol

Synonyms:2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester

Chemical Property of 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester

There total 5 articles about 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

diazoacetic acid ethyl ester (623-73-4) + 3,4-dihydro-2H-5-ethylpyridine-1-carboxylic acid benzyl ester (1246190-33-9) → 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester (1246190-34-0)

Guidance literature:

With copper(I) trifluoromethanesolfonate toluene complex; In dichloromethane; for 18h; Inert atmosphere;

DOI:10.1002/anie.201001853

Reference yield:

piperidin-2-one (675-20-7) → 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester (1246190-34-0)

Guidance literature:

Multi-step reaction with 4 steps

1: n-butyllithium

2: sodium tetrahydroborate

3: sulfuric acid

4: copper(I) triflate

With sodium tetrahydroborate; n-butyllithium; sulfuric acid; copper(I) triflate;

DOI:10.2533/chimia.2012.233

Reference yield:

C15H19NO3 (1246190-43-1) → 2-benzyloxycarbonyl-6-ethyl-2-azabicyclo[4.1.0]heptane-7-carboxylic acid ethyl ester (1246190-34-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate

2: sulfuric acid

3: copper(I) triflate

With sodium tetrahydroborate; sulfuric acid; copper(I) triflate;

DOI:10.2533/chimia.2012.233

upstream raw materials:

diazoacetic acid ethyl ester

3,4-dihydro-2H-5-ethylpyridine-1-carboxylic acid benzyl ester

piperidin-2-one

C₁₅H₁₉NO₃