1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

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Chemical Name:1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide
CAS No.:754193-52-7
Molecular Formula:C₂₆H₂₀F₅N₇O
Molecular Weight:541.483
Hs Code.:

Synonyms:1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

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Chemical Property of 1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

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Technology Process of 1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

There total 6 articles about 1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 754193-48-1
2-fluoro-4-(2-pyrrolidin-1-ylmethylimidazol-1-yl)aniline

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 754193-52-7
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0497949

Reference yield:

: 58610-69-8
2-(pyrrolidin-1-ylmethyl)-1H-imidazole

: 754193-52-7
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / K₂CO₃; CuI / dimethylsulfoxide / 12 h / 120 °C

2: 44 percent / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; copper(l) iodide; potassium carbonate; In dichloromethane; dimethyl sulfoxide; 1: Ullmann coupling;
DOI:10.1021/jm0497949

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 754193-52-7
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

2: 44 percent / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm0497949