2-(pyrrolidin-1-ylmethyl)-1H-imidazole

Base Information

Chemical Name:2-(pyrrolidin-1-ylmethyl)-1H-imidazole
CAS No.:58610-69-8
Molecular Formula:C8H13N3
Molecular Weight:151.20892
Hs Code.:
DSSTox Substance ID:DTXSID90468059
Mol file:58610-69-8.mol

Synonyms:2-(pyrrolidin-1-ylmethyl)-1H-imidazole;58610-69-8;pyrrolidinylmethylimidazole;SCHEMBL1953418;DTXSID90468059;H-BETA-CHLORO-DL-ALA-OHHCL;AKOS006281402

Suppliers and Price of 2-(pyrrolidin-1-ylmethyl)-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(PYRROLIDIN-1-YLMETHYL)-1H-IMIDAZOLE 95.00%
5MG
$ 504.15

AccelPharmtech
2-(1-pyrrolidinylmethyl)-1H-Imidazole 97.00%
25G
$ 4010.00

AccelPharmtech
2-(1-pyrrolidinylmethyl)-1H-Imidazole 97.00%
5G
$ 2180.00

AccelPharmtech
2-(1-pyrrolidinylmethyl)-1H-Imidazole 97.00%
1G
$ 1940.00

Total 6 raw suppliers

Chemical Property of 2-(pyrrolidin-1-ylmethyl)-1H-imidazole

Chemical Property:

PSA：31.92000
LogP:0.94340
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:151.110947427
Heavy Atom Count:11
Complexity:121

Purity/Quality:

99% ^*data from raw suppliers

2-(PYRROLIDIN-1-YLMETHYL)-1H-IMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)CC2=NC=CN2

Technology Process of 2-(pyrrolidin-1-ylmethyl)-1H-imidazole

There total 1 articles about 2-(pyrrolidin-1-ylmethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 123-75-1
pyrrolidine

: 10111-08-7
2-imidazolecarbaldehyde

: 58610-69-8
2-(pyrrolidin-1-ylmethyl)-1H-imidazole

Guidance literature:: With sodium tetrahydroborate; In methanol; at 65 ℃; for 3h;
DOI:10.1021/jm0497949

Reference yield: 77.0%

: 58610-69-8
2-(pyrrolidin-1-ylmethyl)-1H-imidazole

: ethyl 3-(3-(chloromethyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)propanoate

: ethyl 3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((2-(pyrrolidin-1-ylmethyl)-1H-imidazol-1-yl)methyl)phenyl)propanoate

Guidance literature:: 2-(pyrrolidin-1-ylmethyl)-1H-imidazole; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 0.666667h;

ethyl 3-(3-(chloromethyl)-4-methylphenyl)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)propanoate; In N,N-dimethyl-formamide; for 21h;

Reference yield:

: 58610-69-8
2-(pyrrolidin-1-ylmethyl)-1H-imidazole

: 754193-52-7
1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / K₂CO₃; CuI / dimethylsulfoxide / 12 h / 120 °C

2: 44 percent / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; copper(l) iodide; potassium carbonate; In dichloromethane; dimethyl sulfoxide; 1: Ullmann coupling;
DOI:10.1021/jm0497949