[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

Base Information

Chemical Name:[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate
CAS No.:1146352-87-5
Molecular Formula:C₂₄H₃₂O₃
Molecular Weight:368.516
Hs Code.:

Synonyms:[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

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Chemical Property of [(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

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Technology Process of [(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

There total 3 articles about [(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1146352-83-1
[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 2-oxocycloheptanecarboxylate

: 1146352-87-5
[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

Guidance literature:: [(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 2-oxocycloheptanecarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

With N-(tert-butyl)benzenesulfinimidoyl chloride; In tetrahydrofuran; for 0.666667h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol9003405

Reference yield:

: 65253-04-5
(-)-8-phenylmenthol

: 1146352-87-5
[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; benzene / 7 h / Inert atmosphere; Reflux

1.2: 96 h / Inert atmosphere; Reflux

2.1: lithium hexamethyldisilazane; C₁₁H₁₄ClNS / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

With sodium hydride; C₁₁H₁₄ClNS; lithium hexamethyldisilazane; In tetrahydrofuran; mineral oil; benzene;
DOI:10.1021/acs.orglett.8b01087

Reference yield:

: 502-42-1
cycloheptanone

: 1146352-87-5
[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; benzene / 7 h / Inert atmosphere; Reflux

1.2: 96 h / Inert atmosphere; Reflux

2.1: lithium hexamethyldisilazane; C₁₁H₁₄ClNS / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

With sodium hydride; C₁₁H₁₄ClNS; lithium hexamethyldisilazane; In tetrahydrofuran; mineral oil; benzene;
DOI:10.1021/acs.orglett.8b01087