C₂₃H₃₄O

Base Information

• Chemical Name: C₂₃H₃₄O
• CAS No.: 1395881-48-7
• Molecular Formula: C₂₃H₃₄O
• Molecular Weight: 326.522
• Mol file: 1395881-48-7.mol

Synonyms:C₂₃H₃₄O

Chemical Property of C₂₃H₃₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₃₄O

There total 5 articles about C₂₃H₃₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-bromo-butane (109-65-9) + (1R,2S)-1-(2-hydroxyethyl)-1,2,5,5-tetramethyl-Δ4a(8a)-octahydronaphthalene (122508-18-3) → C23H34O (1395881-48-7)

Guidance literature:

(1R,2S)-1-(2-hydroxyethyl)-1,2,5,5-tetramethyl-Δ^4a(8a)-octahydronaphthalene; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h;

1-bromo-butane; In tetrahydrofuran; at 20 ℃; Cooling;

DOI:10.1021/ol301715u DOI:10.1021/ol301715u

Reference yield:

(3aR)-(+)-sclareolide (564-20-5,1216-84-8,30450-17-0,58976-28-6,64090-92-2,67844-42-2,79768-41-5,79768-42-6,86688-27-9,86688-28-0,95406-08-9,98719-44-9,98719-46-1,131831-65-7,140851-80-5) → C23H34O (1395881-48-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2.1: dmap; pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate / dichloromethane / 12 h / 20 °C

4.1: potassium hydroxide / methanol / 0.5 h / 20 °C

5.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

5.2: 20 °C / Cooling

With pyridine; dmap; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

DOI:10.1021/ol301715u DOI:10.1021/ol301715u

Reference yield:

(1R,2R,4aS,8aS)-(+)-1-(2'-acetoxyethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydro-2-hydroxy-2,5,5,8a-tetramethylnaphthalene (64061-39-8) → C23H34O (1395881-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 12 h / 20 °C

2.1: potassium hydroxide / methanol / 0.5 h / 20 °C

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

3.2: 20 °C / Cooling

With boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;

DOI:10.1021/ol301715u DOI:10.1021/ol301715u

upstream raw materials:

(3aR)-(+)-sclareolide

1-bromo-butane

(1R,2S)-1-(2-hydroxyethyl)-1,2,5,5-tetramethyl-Δ^4a(8a)-octahydronaphthalene

(1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol

Downstream raw materials:

C₃₃H₅₈O₃Si₂

C₃₃H₅₈O₂Si₂

2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol

Aureol