3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

Base Information

Chemical Name:3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene
CAS No.:116653-46-4
Molecular Formula:C₄₄H₄₈N₂O₇S
Molecular Weight:748.94
Hs Code.:

Synonyms:3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

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Chemical Property of 3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

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Technology Process of 3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

There total 2 articles about 3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 116653-45-3
3β-benzoyloxy-22-hydroxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-23,24-bisnorchol-6-ene

: 98-59-9
p-toluenesulfonyl chloride

: 116653-46-4
3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

Guidance literature:: With pyridine; at 0 ℃; for 5h;

Reference yield:

: 81126-45-6
3β-benzoyloxy-5α,8α-ergosta-6,22-dieno-<5,8-b>1',2',3',4'-tetrahydrophthalazino-1',4'-dione

: 116653-46-4
3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, pyridine, -60 deg C, 10 min, 2.) MeOH, CH₂Cl₂, -50 deg, 10 min, then room temp., 2h

2: 81 percent / pyridine / 5 h / 0 °C

With pyridine; sodium tetrahydroborate; ozone;

Reference yield:

: 116653-46-4
3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene

: 104729-36-4
3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LiBr*2H₂O, Li₂CO₃ / 1.) DMF, 80 deg C, 1h, 2.) 80 deg C, 3h

2: 89 percent / LiAlH₄ / tetrahydrofuran / 20 deg C, 20 min, then reflux, 20 min

With lithium aluminium tetrahydride; lithium carbonate; lithium bromide; In tetrahydrofuran;