4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

Base Information

Chemical Name:4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol
CAS No.:1010113-49-1
Molecular Formula:C₁₆H₁₆N₂O₂S
Molecular Weight:300.381
Hs Code.:

Synonyms:4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

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Chemical Property of 4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

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Technology Process of 4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

There total 4 articles about 4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-ethyl-thiophene-2-carboxylic acid (4,N-dihydroxy-3,5-dimethyl-benzamidine) ester

: 1010113-49-1
4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

Guidance literature:: In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield:

: 23229-72-3
5-ethyl-2-thiophenecarboxylic acid

: 162854-15-1
N,4-dihydroxy-3,5-dimethylbenzimidamide

: 1010113-49-1
4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

Guidance literature:: 5-ethyl-2-thiophenecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

N,4-dihydroxy-3,5-dimethylbenzimidamide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm401456d

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 1010113-49-1
4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate; hydroxylamine hydrochloride / methanol / 32.5 h / Reflux

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 18 h / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401456d