23229-72-3

Basic information

• Product Name: 5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BE 0391;AKOS MSC-0715;AKOS B000094;5-ETHYL-2-THIOPHENECARBOXYLIC ACID;5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID;ASINEX-REAG BAS 10238292;ART-CHEM-BB B000094;CHEMBRDG-BB 4402392
• CAS NO: 23229-72-3
• Molecular Formula: C₇H₈O₂S
• Molecular Weight: 156.2
• Mol File: 23229-72-3.mol

Chemical Properties

• Melting Point: 69 °C
• Boiling Point: 286.1 °C at 760 mmHg
• Flash Point: 126.8 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0.00126mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: 5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID(23229-72-3)
• EPA Substance Registry System: 5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID(23229-72-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23229-72-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
5-Ethyl-thiophene-2-carboxylic Acid is used as a chemical intermediate for the synthesis of various compounds in the chemical industry. Its unique structure and reactivity make it a valuable building block for the creation of new molecules with potential applications in different fields.
Used in Pharmaceutical Industry:
5-Ethyl-thiophene-2-carboxylic Acid is used as a key component in the development of pharmaceuticals. Its structural features allow it to be incorporated into drug molecules, potentially leading to the discovery of new therapeutic agents with improved efficacy and safety profiles.
Used in Material Science:
5-Ethyl-thiophene-2-carboxylic Acid is used as a component in the development of advanced materials, such as polymers and composites. Its incorporation into these materials can enhance their properties, such as conductivity, stability, and mechanical strength, making them suitable for various applications in industries like electronics, automotive, and aerospace.
Used in Research and Development:
5-Ethyl-thiophene-2-carboxylic Acid is used as a research compound in academic and industrial laboratories. Its unique properties and reactivity make it an interesting subject for studies aimed at understanding its behavior and potential applications in various fields, such as catalysis, sensors, and energy storage.
Used in Environmental Applications:
5-Ethyl-thiophene-2-carboxylic Acid may be used in environmental applications, such as the remediation of contaminated sites or the development of eco-friendly materials. Its chemical properties could potentially be harnessed to improve the efficiency of these processes and contribute to a more sustainable future.

InChI:InChI=1/C7H8O2S/c1-2-5-3-4-6(10-5)7(8)9/h3-4H,2H2,1H3,(H,8,9)

Upstream product

• 36880-33-8 5-ethyl-thiophene-2-carbaldehyde 
• 62323-44-8 2-bromo-5-ethylthiophene 
• 33252-91-4 5-ethyl-2-iodothiophene 
• 541-41-3 chloroformic acid ethyl ester 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 
• 18761-46-1 1-(5-ethyl-thiophen-2-yl)-ethanone 
• 527-72-0 2-thiophenylcarboxylic acid 
• 75-03-6 ethyl iodide 
• 872-55-9 2-ethylthiophene 
• 59753-16-1 C₅H₂O₂S^(2-)*2Li⁽¹⁺⁾ 

Downstream Products

• 64964-17-6 5-Ethyl-2-thiophencarbonsaeurechlorid 
• 6933-26-2 (5-ethyl-2-thienyl)phenylmethanone 
• 1400704-84-8 (S)-[(5-ethyl-thiophene-2-carbonyl)amino]-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-propionic acid methyl ester 
• 1010113-49-1 4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol 
• 1010114-08-5 (S)-N-(3-{4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide 
• 1010113-62-8 1-amino-3-{4-[5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propan-2-ol 
• 1010113-59-3 3-(3,5-dimethyl-4-oxiranylmethoxy-phenyl)-5-(5-ethyl-thiophen-2-yl)-[1,2,4]oxadiazole 
• 111-14-8 oenanthic acid 

Relevant articles and documents

Novel S1P1 receptor agonists - Part 2: From bicyclo[3.1.0] hexane-fused thiophenes to isobutyl substituted thiophenes

Previously, we reported on the discovery of a novel series of bicyclo[3.1.0]hexane fused thiophene derivatives that serve as potent and selective S1P1 receptor agonists. Here, we discuss our efforts to simplify the bicyclohexane fused thiophene

Thiophene derivatives as S1P1/EDGE1 receptor agonists

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

NOVEL THIOPHENE DERIVATIVES

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

Phosphorylamides, their preparation and use

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.

TETRACYCLIC COMPOUNDS AS DOPAMINE AGONISTS

A tetracyclic compound of the formula: STR1 wherein A and the atoms to which it is attached and the optional double bond represent a mono-or di-heterocyclic ring selected from: STR2 wherein R 1, R. sup.2, R 3, R 4 and X are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder.

Generation and Synthetic Utility of Dianions Derived from Thiophencarboxylic Acids

Thiophen-2- and -3-carboxylic acid are rapidly and regioselectively metallated by lithium di-isopropylamide in tetrahydrofuran at -78 deg C.The resulting dianionic species react with a range of electrophiles to give the expected thiophencarboxylic acid homologues in good-to-excellent yields.

Formation and reactivity of dianions derived from 2- and 3-thiophencarboxylic acids

Dianions (3) and (6) can be generated in high yield from the corresponding thiophencarboxylic acids with lithium diisopropylamide and react with a number of representative electrophiles to give fair to good yields of 5-substituted-thiophen-2-carboxylic acids and 2-substituted thiophen-3-carboxylic acids respectively.