N-[4-(PHENYLMETHOXY)PHENYL]-2-[(PHENYLMETHYL)AMINO]-ACETAMIDE

Base Information

• Chemical Name: N-[4-(PHENYLMETHOXY)PHENYL]-2-[(PHENYLMETHYL)AMINO]-ACETAMIDE
• CAS No.: 777934-39-1
• Molecular Formula: C22H22 N2 O2
• Molecular Weight: 346.429
• Hs Code.: 2924299090
• Mol file: 777934-39-1.mol

Synonyms:2-Benzylamino-N-(4-benzyloxyphenyl)acetamide

Chemical Property of N-[4-(PHENYLMETHOXY)PHENYL]-2-[(PHENYLMETHYL)AMINO]-ACETAMIDE

Chemical Property:

• Vapor Pressure: 9.98E-13mmHg at 25°C
• Refractive Index: 1.63
• Boiling Point: 563.6°C at 760 mmHg
• Flash Point: 294.7°C
• PSA: 50.36000
• Density: 1.181g/cm³
• LogP: 4.45780

Purity/Quality:

95% ^*data from raw suppliers

N-[4-(PHENYLMETHOXY)PHENYL]-2-[(PHENYLMETHYL)AMINO]ACETAMIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[4-(PHENYLMETHOXY)PHENYL]-2-[(PHENYLMETHYL)AMINO]-ACETAMIDE

There total 3 articles about N-[4-(PHENYLMETHOXY)PHENYL]-2-[(PHENYLMETHYL)AMINO]-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-[4-(benzyloxy)phenyl]-2-chloroacetamide (19514-92-2) + benzylamine (100-46-9) → 2-benzylamino-N-(4-benzyloxyphenyl)acetamide (777934-39-1)

Guidance literature:

In tetrahydrofuran; for 18h; Heating;

DOI:10.1021/ol048235t

Reference yield: 68.0%

benzyl-[(4-benzyloxyphenylcarbamoyl)-methyl]carbamic acid tert-butyl ester (777934-40-4) → 2-benzylamino-N-(4-benzyloxyphenyl)acetamide (777934-39-1)

Guidance literature:

With hydrogenchloride; In methanol; water; for 18h; Heating / reflux;

Reference yield:

4-benzyloxyaniline hydrochloride (51388-20-6) → 2-benzylamino-N-(4-benzyloxyphenyl)acetamide (777934-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃ / tetrahydrofuran / 6 h / 20 °C

2: 93 percent / tetrahydrofuran / 18 h / Heating

With potassium carbonate; In tetrahydrofuran;

DOI:10.1021/ol048235t

upstream raw materials:

N-[4-(benzyloxy)phenyl]-2-chloroacetamide

benzylamine

4-benzyloxyaniline hydrochloride

benzyl-[(4-benzyloxyphenylcarbamoyl)-methyl]carbamic acid tert-butyl ester

Downstream raw materials:

2-{benzyl[(2S)-3-chloro-2-hydroxypropyl]amino}-N-(4-benzyloxyphenyl)acetamide

(3R)-3-hydroxymethyl-4-(4-hydroxyphenyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester