N-(4-Benzyloxy-phenyl)-2-chloro-acetamide

Base Information

• Chemical Name: N-(4-Benzyloxy-phenyl)-2-chloro-acetamide
• CAS No.: 19514-92-2
• Molecular Formula: C15H14 Cl N O2
• Molecular Weight: 275.735
• Hs Code.: 2924299090
• European Community (EC) Number: 675-753-7
• DSSTox Substance ID: DTXSID10355250
• Wikidata: Q82134022
• Mol file: 19514-92-2.mol

Synonyms:19514-92-2;N-(4-Benzyloxy-phenyl)-2-chloro-acetamide;N-(4-(Benzyloxy)phenyl)-2-chloroacetamide;n-[4-(benzyloxy)phenyl]-2-chloroacetamide;2-chloro-N-(4-phenylmethoxyphenyl)acetamide;N-(4-Benzyloxyphenyl)-2-chloroacetamide;SCHEMBL3224230;DTXSID10355250;TUTQONMCEZLRPX-UHFFFAOYSA-N;MFCD00791335;AKOS000115068;AS-36345;CS-0171395;FT-0637866;EN300-01517;2-chloro-n-[4-(phenylmethoxy)phenyl]-acetamide;A813786;Z56862612

Chemical Property of N-(4-Benzyloxy-phenyl)-2-chloro-acetamide

Chemical Property:

• Vapor Pressure: 2.56E-09mmHg at 25°C
• Melting Point: 132-134 °C
• Boiling Point: 478.5°Cat760mmHg
• PKA: 12.31±0.70(Predicted)
• Flash Point: 243.2°C
• PSA: 38.33000
• Density: 1.261g/cm³
• LogP: 3.51590
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 275.0713064
• Heavy Atom Count: 19
• Complexity: 271

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Benzyloxyphenyl)-2-chloroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)NC(=O)CCl

Technology Process of N-(4-Benzyloxy-phenyl)-2-chloro-acetamide

There total 7 articles about N-(4-Benzyloxy-phenyl)-2-chloro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-benzyloxyaniline hydrochloride (51388-20-6) + chloroacetyl chloride (79-04-9) → N-[4-(benzyloxy)phenyl]-2-chloroacetamide (19514-92-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1021/ol048235t

Reference yield: 88.0%

p-benzylaniline (1135-12-2) + chloroacetyl chloride (79-04-9) → N-[4-(benzyloxy)phenyl]-2-chloroacetamide (19514-92-2)

Guidance literature:

With potassium carbonate; In 1,2-dichloro-ethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2015.09.033

Reference yield: 82.0%

p-benzyloxyaniline (6373-46-2) + chloroacetyl chloride (79-04-9) → N-[4-(benzyloxy)phenyl]-2-chloroacetamide (19514-92-2)

Guidance literature:

With pyridine; In dichloromethane; at -10 - 20 ℃; for 3.5h;

DOI:10.1016/j.bmcl.2010.10.099

upstream raw materials:

p-benzyloxyaniline

chloroacetyl chloride

4-benzyloxyaniline hydrochloride

p-benzylaniline

Downstream raw materials:

N,N-diethyl-glycine-(4-benzyloxy-anilide)

2-benzylamino-N-(4-benzyloxyphenyl)acetamide

(3R)-3-hydroxymethyl-4-(4-hydroxyphenyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester

(6R)-4-benzyl-1-(4-benzyloxyphenyl)-6-hydroxymethylpiperazin-2-one