(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

Base Information

Chemical Name:(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride
CAS No.:1403884-22-9
Molecular Formula:C₁₇H₁₄ClF₂NO₄
Molecular Weight:369.752
Hs Code.:

Synonyms:(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

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Chemical Property of (R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

Chemical Property:

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Technology Process of (R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

There total 5 articles about (R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403884-21-8
(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoic acid

: 1403884-22-9
(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 130111-08-9,127744-27-8
(S)-3-(benzyloxy)-2-hydroxypropanoic acid

: 1403884-22-9
(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48.66 h / 0 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.2: pH 4

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

With oxalyl dichloride; sulfuric acid; water; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 1403884-22-9
(R)-3-(benzyloxy)-2-(3-carbamoyl-2,4-difluorophenoxy)propanoyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 0.75 h / 20 °C

1.2: 20 h / 5 - 20 °C / pH 4

2.1: sulfuric acid / 16 h / Reflux

3.1: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 48.66 h / 0 - 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4.2: pH 4

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

With oxalyl dichloride; sulfuric acid; water; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;