2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Base Information

Chemical Name:2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile
CAS No.:916176-67-5
Molecular Formula:C₂₃H₂₀N₄O₂S
Molecular Weight:416.503
Hs Code.:

Synonyms:2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Suppliers and Price of 2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

There total 4 articles about 2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 916176-84-6
2-(6-chloropyridin-2-yl)-2-methylpropanenitrile

: 916176-50-6
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 916176-67-5
2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 160 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 4-bromo-1H-pyrrolo[2,3-b]pyridine

: 916176-67-5
2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 160 °C / microwave irradiation

With potassium acetate; sodium hydride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 348640-07-3
4-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 916176-67-5
2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 160 °C / microwave irradiation

With potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water;