1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil

Base Information

• Chemical Name: 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil
• CAS No.: 537041-12-6
• Molecular Formula: C₃₁H₃₀N₂O₅
• Molecular Weight: 510.59
• Mol file: 537041-12-6.mol

Synonyms:1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil

Chemical Property of 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil

There total 3 articles about 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propionaldehyde (537041-04-6) → 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil (537041-12-6)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; (1,4,7,10-tetraoxacyclododecane); In tetrahydrofuran; at -78 ℃;

(R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propionaldehyde; In tetrahydrofuran; at 20 ℃; for 48h; Further stages.;

DOI:10.1002/ejoc.200390107

Reference yield: 5.0%

(R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propionaldehyde (537041-04-6) + 1,1-dibromomethane (74-95-3) → 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil (537041-12-6)

Guidance literature:

With zinc; Further Variations:; Reagents; Product distribution;

DOI:10.1002/ejoc.200390107

Reference yield:

1-(1-{1-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-prop-2-ynyloxy}-prop-2-ynyl)-1H-pyrimidine-2,4-dione → 1-[1-({1-[(monomethoxytrityl)methyl]-2-propenyl}oxy)-2-propenyl]-uracil (537041-12-6) + 1-((S)-1-{(S)-1-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-allyloxy}-allyl)-1H-pyrimidine-2,4-dione

Guidance literature:

With quinoline; hydrogen; Lindlar's catalyst; In methanol; at 20 ℃; for 18h; Title compound not separated from byproducts.;

DOI:10.1002/ejoc.200390107

upstream raw materials:

Methyltriphenylphosphonium bromide

(R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propionaldehyde

1,1-dibromomethane

Downstream raw materials:

1-(5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-β-D-glycero-pent-2'-eno-furanosyl)uracil