9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

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Chemical Name:9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione
CAS No.:91284-85-4
Molecular Formula:C₂₀H₂₁N₅O₄
Molecular Weight:395.418
Hs Code.:

Synonyms:9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

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Chemical Property of 9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

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Technology Process of 9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

There total 3 articles about 9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 57000-13-2
8-(benzylamino)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

: 2163-48-6
diethyl propylmalonate

: 91284-85-4
9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

Guidance literature:: With sodium methylate; at 200 - 210 ℃; for 9h;
DOI:10.1021/jm00156a032

Reference yield:

: 100-46-9
benzylamine

: 91284-85-4
9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 4 h / Heating

2: 67 percent / NaOMe / 9 h / 200 - 210 °C

With sodium methylate;
DOI:10.1021/jm00156a032

Reference yield:

: 107-08-4
1-iodo-propane

: 91285-01-7
9-benzyl-1,3-dimethyl-6-(hydroxy)pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

: 91284-85-4
9-Benzyl-1,3-dimethyl-6-hydroxy-7-(n-propyl)-pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

: 8-Benzyl-1,3-dimethyl-6,6-dipropyl-1H,8H-1,3,4b,8,9-pentaaza-fluorene-2,4,5,7-tetraone

Guidance literature:: With 15-crown-5; sodium hydride; Multistep reaction. Title compound not separated from byproducts; 1.) DMF, 2.) DMF, 50-95 deg C, 60 h;