2-acetyl-6-isopropylpyridine

Base Information

• Chemical Name: 2-acetyl-6-isopropylpyridine
• CAS No.: 900816-50-4
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 900816-50-4.mol

Synonyms:2-acetyl-6-isopropylpyridine

Chemical Property of 2-acetyl-6-isopropylpyridine

Chemical Property:

• Boiling Point: 225.0±20.0 °C(Predicted)
• Density: 0.993±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

1-(6-Isopropylpyridin-2-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-6-isopropylpyridine

There total 5 articles about 2-acetyl-6-isopropylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

methyllithium (917-54-4) + 6-isopropylpyridine-2-carbonitrile (337904-76-4) → 2-acetyl-6-isopropylpyridine (900816-50-4)

Guidance literature:

methyllithium; 6-isopropylpyridine-2-carbonitrile; In diethyl ether; at -25 ℃;

With hydrogenchloride; water;

DOI:10.1002/ejic.200500645

Reference yield:

methylmagnesium bromide (75-16-1) + 6-isopropylpyridine-2-carbonitrile (337904-76-4) → 2-acetyl-6-isopropylpyridine (900816-50-4)

Guidance literature:

methylmagnesium bromide; 6-isopropylpyridine-2-carbonitrile; In tetrahydrofuran; diethyl ether; at -25 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 4.16667h; Inert atmosphere;

DOI:10.1039/c9ob00770a

Reference yield:

2-isopropylpyridine (644-98-4) → 2-acetyl-6-isopropylpyridine (900816-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 79 percent / m-chloroperbenzoic acid / CHCl₃ / 0 °C

2.1: 61 percent / dimethylcarbamoyl chloride / CH₂Cl₂ / 48 h / 20 °C

3.1: diethyl ether / -25 °C

3.2: 25 percent / H₂O; NH₃Cl; HCl

With 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In diethyl ether; dichloromethane; chloroform;

DOI:10.1002/ejic.200500645

upstream raw materials:

methyllithium

6-isopropylpyridine-2-carbonitrile

2-Ethylpyridine

2-isopropylpyridine

Downstream raw materials:

2-[1-(2,6-diisopropylphenylimino)ethyl]-6-isopropylpyridine N-oxide

(2,6-diisopropylphenyl)[1-(6-isopropylpyridin-2-yl)ethylidene]amine