(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Base Information

Chemical Name:(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester
CAS No.:250608-87-8
Molecular Formula:C₅₉H₆₈N₄O₉SSi
Molecular Weight:1037.36
Hs Code.:

(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Synonyms:(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Suppliers and Price of (R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

There total 13 articles about (R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 250608-86-7
C₆₆H₇₄N₄O₁₁S₂Si

: 250608-87-8
(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Guidance literature:: With α,α,α-trifluorotoluene; ammonium chloride; magnesium; In ethanol; at 20 ℃; for 5h;
DOI:10.1021/ol990990x

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 250608-87-8
(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: K₂OsO₂(OH)4; (DHQD)2PHAL / propan-1-ol; H₂O

2: 62 percent / I₂; Ag₂SO₄ / ethanol

3: 90 percent / Me₃SiI / ethane-1,2-diamine

4: 75 percent / EDCI; HOBt; NMM / acetonitrile / 2 h / 20 °C

5: imidazole / CH₂Cl₂ / 4 h / 20 °C

6: 75 percent / KOAc / PdCl₂(dppf) / dimethylsulfoxide / 40 h / 80 °C

7: 55 percent / K2CO3; α,a,α-trifluorotopuene / PdCl2(dppf) / 1,2-dimethoxy-ethane / 20 h / 80 °C

8: 97 percent / Mg; NH4Cl; α,α,α-trifluorotoluene / ethanol / 5 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; potassium dioxotetrahydroxoosmate(VI); trimethylsilyl iodide; α,α,α-trifluorotoluene; iodine; potassium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; silver sulfate; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,4-bis(9-O-dihydroquinidine)phthalazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In propan-1-ol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; ethylenediamine; acetonitrile; 1: Sharpless aminohydroxylation / 7: Suzuki coupling;
DOI:10.1021/ol990990x

Reference yield:

: 250608-82-3
R-2-amino-2-(3-iodo-4-methoxy)phenyl-ethanol

: 250608-87-8
(R,R,R)-3-[6-{5-[1-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-phenyl}-1H-indol-3-yl]-2-(toluene-4-sulfonylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / EDCI; HOBt; NMM / acetonitrile / 2 h / 20 °C

2: imidazole / CH₂Cl₂ / 4 h / 20 °C

3: 75 percent / KOAc / PdCl₂(dppf) / dimethylsulfoxide / 40 h / 80 °C

4: 55 percent / K2CO3; α,a,α-trifluorotopuene / PdCl2(dppf) / 1,2-dimethoxy-ethane / 20 h / 80 °C

5: 97 percent / Mg; NH4Cl; α,α,α-trifluorotoluene / ethanol / 5 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; α,α,α-trifluorotoluene; potassium acetate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 4: Suzuki coupling;
DOI:10.1021/ol990990x