(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
CAS No.:250608-85-6
Molecular Formula:C₄₅H₅₉BN₂O₇Si
Molecular Weight:778.869
Hs Code.:

(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Synonyms:(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of (R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Technology Process of (R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

There total 6 articles about (R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 250608-84-5
(R,R)-{1-[2-(tert-butyl-diphenyl-silanyloxy)-1-(3-iodo-4-methoxy-phenyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

: 73183-34-3
bis(pinacol)diborane

: 250608-85-6
(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 40h;
DOI:10.1021/ol990990x

Reference yield:

: 637-69-4,24936-44-5
4-Methoxystyrene

: 250608-85-6
(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂OsO₂(OH)4; (DHQD)2PHAL / propan-1-ol; H₂O

2: 62 percent / I₂; Ag₂SO₄ / ethanol

3: 90 percent / Me₃SiI / ethane-1,2-diamine

4: 75 percent / EDCI; HOBt; NMM / acetonitrile / 2 h / 20 °C

5: imidazole / CH₂Cl₂ / 4 h / 20 °C

6: 75 percent / KOAc / PdCl₂(dppf) / dimethylsulfoxide / 40 h / 80 °C

With 4-methyl-morpholine; 1H-imidazole; potassium dioxotetrahydroxoosmate(VI); trimethylsilyl iodide; iodine; potassium acetate; benzotriazol-1-ol; silver sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,4-bis(9-O-dihydroquinidine)phthalazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In propan-1-ol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethylenediamine; acetonitrile; 1: Sharpless aminohydroxylation;
DOI:10.1021/ol990990x

Reference yield:

: 250608-83-4
C₂₃H₂₉IN₂O₅

: 250608-85-6
(R,R)-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[4-methoxy-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / CH₂Cl₂ / 4 h / 20 °C

2: 75 percent / KOAc / PdCl₂(dppf) / dimethylsulfoxide / 40 h / 80 °C

With 1H-imidazole; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol990990x