((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

Base Information

Chemical Name:((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol
CAS No.:190506-34-4
Molecular Formula:C₂₄H₃₂FN₅O₆Si
Molecular Weight:533.632
Hs Code.:

Synonyms:((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

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Chemical Property of ((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

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Technology Process of ((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

There total 1 articles about ((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 147299-48-7
3'-O,5'-O-bis(tert-butyldimethylsilyl)-O⁶-(2''-(4'''-nitrophenyl)ethyl)-2'-deoxyguanosine

: 190506-34-4
((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

: 190506-33-3
3′,5′-O-bis(tert-butyldimethylsilyl)-O⁶-(p-nitrophenylethyl)-2′-deoxy-2-fluoroguanosine

Guidance literature:: With tert.-butylnitrite; polyvinylpyridinium polyhydrogenfluoride; In toluene; at -5 - 0 ℃; for 0.5h; Yield given;
DOI:10.1016/S0040-4039(97)00540-6

Reference yield:

: 190506-34-4
((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

: 132183-39-2
2-fluoro-O⁶-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dioxane / 16 h / Ambient temperature

2: 90 percent / triethylamine trihydrofluoride / tetrahydrofuran / 24 h / Ambient temperature

With 1H-imidazole; triethylamine trihydrofluoride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/S0040-4039(97)00540-6

Reference yield:

: 190506-34-4
((2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-{2-fluoro-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-2-yl)-methanol

: 153527-28-7
5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dioxane / 16 h / Ambient temperature

2: 90 percent / triethylamine trihydrofluoride / tetrahydrofuran / 24 h / Ambient temperature

3: 87 percent / pyridine, DMAP

With pyridine; 1H-imidazole; dmap; triethylamine trihydrofluoride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/S0040-4039(97)00540-6