5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Base Information

Chemical Name:5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine
CAS No.:153527-28-7
Molecular Formula:C₃₉H₃₆FN₅O₈
Molecular Weight:721.742
Hs Code.:

Synonyms:5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Suppliers and Price of 5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

There total 15 articles about 5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 132183-39-2
2-fluoro-O⁶-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine

: 153527-28-7
5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Guidance literature:: With pyridine; for 3h;
DOI:10.1080/07328319908044615

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 153527-28-7
5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / PPh₃; DEAD / dioxane / 24 h

2: 75 percent / poly[4-vinylpyridinium poly(hydrogen fluoride)]; t-BuONO / toluene / -65 - -5 °C

3: 88 percent / TEA*3HF / tetrahydrofuran / 17 h / 20 °C

4: 76 percent / pyridine / 17 h

With pyridine; tert.-butylnitrite; poly[4-vinylpyridinium poly(hydrogen fluoride)]; triethylamine tris(hydrogen fluoride); triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1002/1521-3765(20001117)6:22<4188::AID-CHEM4188>3.0.CO;2-N

Reference yield:

: 147299-48-7
3'-O,5'-O-bis(tert-butyldimethylsilyl)-O⁶-(2''-(4'''-nitrophenyl)ethyl)-2'-deoxyguanosine

: 153527-28-7
5'-O-(4,4'-Dimethoxytrityl)-6-O-[2-(4-nitrophenyl)ethyl]-2'-deoxy-2-fluoroinosine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / poly[4-vinylpyridinium poly(hydrogen fluoride)]; t-BuONO / toluene / -65 - -5 °C

2: 88 percent / TEA*3HF / tetrahydrofuran / 17 h / 20 °C

3: 76 percent / pyridine / 17 h

With pyridine; tert.-butylnitrite; poly[4-vinylpyridinium poly(hydrogen fluoride)]; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; toluene;
DOI:10.1002/1521-3765(20001117)6:22<4188::AID-CHEM4188>3.0.CO;2-N