(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid
CAS No.:1242441-49-1
Molecular Formula:C₁₈H₁₄ClN₃O₂S
Molecular Weight:371.847
Hs Code.:

Synonyms:(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Suppliers and Price of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Matrix Scientific
(1S,2S)-2-(4-(5-((5-Chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid 97%
1g
$ 8640.00

Total 1 raw suppliers

Chemical Property of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

(1S,2S)-2-(4-(5-((5-Chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid 97% ^*data from reagent suppliers

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Hazard Codes:

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Technology Process of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

There total 7 articles about (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242441-48-0
(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1242441-49-1
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate; With water; potassium hydroxide; In acetonitrile; at 80 ℃; for 0.5h;

With hydrogenchloride; In water; acetonitrile; pH=6;

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1242441-49-1
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

1.2: 1 h / 20 °C

1.3: 4 h / Reflux

2.1: hydrogenchloride / methanol / 2 h / Reflux

3.1: potassium carbonate; copper(l) iodide; 1,10-Phenanthroline / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

4.1: potassium hydroxide; water / acetonitrile / 0.5 h / 80 °C

With hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; ethylmagnesium bromide; water; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/ml4000996

Reference yield:

: 40771-41-3
2-mercapto-5-chloro-pyridine

: 1242441-49-1
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; copper(l) iodide; 1,10-Phenanthroline / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

2: potassium hydroxide; water / acetonitrile / 0.5 h / 80 °C

With copper(l) iodide; 1,10-Phenanthroline; water; potassium carbonate; potassium hydroxide; In dimethyl sulfoxide; acetonitrile;
DOI:10.1021/ml4000996