(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide
CAS No.:1242441-47-9
Molecular Formula:C₂₀H₁₉ClN₄OS
Molecular Weight:398.916
Hs Code.:

Synonyms:(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Suppliers and Price of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

There total 8 articles about (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1242441-49-1
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid

: 124-40-3
dimethyl amine

: 1242441-47-9
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 0.5 - 1h;

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1242441-47-9
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethylmagnesium bromide / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

1.2: 1 h / 20 °C

1.3: 4 h / Reflux

2.1: hydrogenchloride / methanol / 2 h / Reflux

3.1: potassium carbonate; copper(l) iodide; 1,10-Phenanthroline / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

4.1: potassium hydroxide; water / acetonitrile / 0.5 h / 80 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 80 °C

With hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; ethylmagnesium bromide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4000996

Reference yield:

: 1242440-99-8
(1S,2S)-ethyl 2-(4-(1-trityl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1242441-47-9
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)-N,Ndimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol / 2 h / Reflux

2: potassium carbonate; copper(l) iodide; 1,10-Phenanthroline / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere

3: potassium hydroxide; water / acetonitrile / 0.5 h / 80 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 80 °C

With hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml4000996