(S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

Base Information

Chemical Name:(S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one
CAS No.:1104077-80-6
Molecular Formula:C₂₀H₁₄F₅NO₃
Molecular Weight:411.328
Hs Code.:

Synonyms:(S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

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Chemical Property of (S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

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Technology Process of (S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

There total 2 articles about (S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1104077-72-6
(E)-3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoic acid

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 1104077-80-6
(S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

Guidance literature:: With pivaloyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; at -23 - 20 ℃; Large scale reaction;
DOI:10.1021/op900216v

Reference yield: 71.0%

: C₁₅H₁₃F₅O₃

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 1104077-80-6
(S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

Guidance literature:: (S)-4-Benzyl-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

C₁₅H₁₃F₅O₃; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16.5h;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 0 ℃;

Reference yield: 65.0%

: 1104077-80-6
(S,E)-4-benzyl-3-(3-(3,5-difluorophenyl)-4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

: 1104077-74-8
(S)-4-benzyl-3-((S)-3-(3,5-difluorophenyl)-4,4,4-trifluorobutanoyl)oxazolidin-2-one

Guidance literature:: With hydrogen; magnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; at 45 - 50 ℃; for 4h; under 3345.86 - 4121.6 Torr;