4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane

Base Information

• Chemical Name: 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane
• CAS No.: 118074-98-9
• Molecular Formula: C₂₆H₄₀N₄O₆S₂
• Molecular Weight: 568.759
• Mol file: 118074-98-9.mol

Synonyms:4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane

Chemical Property of 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane

There total 2 articles about 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(p-toluenesulfonyl)aziridine (3634-89-7) + diaza[12]crown-4 (294-92-8) → 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane (118074-98-9)

Guidance literature:

In acetonitrile; Heating;

Reference yield:

4,10-bis(p-tolylsulphonyl)-1,7-dioxa-4,10-diazacyclododecane (52601-77-1) → 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane (118074-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

2: 92 percent / acetonitrile / 1 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;

Reference yield: 81.0%

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + 4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane (118074-98-9) → 4,10-bis(p-tolylsulphonyl)-7,16,21-trioxa-1,4,10,13-tetra-azabicyclo<11.5.5>tricosane (118074-99-0)

Guidance literature:

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In toluene; for 16h; Heating;

upstream raw materials:

N-(p-toluenesulfonyl)aziridine

diaza[12]crown-4

4,10-bis(p-tolylsulphonyl)-1,7-dioxa-4,10-diazacyclododecane

Downstream raw materials:

4,10-bis(p-tolylsulphonyl)-7,16,21-trioxa-1,4,10,13-tetra-azabicyclo<11.5.5>tricosane

4,11-bis(p-tolylsulphonyl)-6,9-etheno-17,22-dioxa-1,4,11,14-tetra-azabicyclo<12.5.5>tetracosa-6,8-diene

4,13-bis(p-tolylsulphonyl)-7,10,19,24-tetraoxa-1,4,13,16-tetra-azabicyclo<14.5.5>hexacosane

4,7-bis(p-tolylsulphonyl)-13,18-dioxa-1,4,7,10-tetra-azabicyclo<8,5,5>icosane