dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Base Information

Chemical Name:dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate
CAS No.:1609632-80-5
Molecular Formula:C₄₁H₃₈N₂O₁₀S₂
Molecular Weight:782.892
Hs Code.:

Synonyms:dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Suppliers and Price of dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

There total 4 articles about dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1310491-87-2
methyl 4-(3-{[(4-methylphenyl)sulfonyl]amino}prop-1-yn-1-yl)benzoate

: 41658-03-1
ethyl 3-bromoprop-2-ynoate

: 1609632-80-5
dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Guidance literature:: With potassium phosphate; In toluene; at 70 ℃; for 7h; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol501125r

Reference yield:

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1609632-80-5
dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 4 h / 20 °C / Schlenk technique; Inert atmosphere

2: potassium phosphate / toluene / 7 h / 70 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; triethylamine; In tetrahydrofuran; toluene; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/ol501125r

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1609632-80-5
dimethyl 4,4'-(3,3'-(3-ethoxy-3-oxoprop-1-ene-1,1-diyl)bis(tosylazanediyl)bis(prop-1-yne-3,1-diyl))dibenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / Schlenk technique; Inert atmosphere

2: trifluoroacetic acid / Schlenk technique; Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 4 h / 20 °C / Schlenk technique; Inert atmosphere

4: potassium phosphate / toluene / 7 h / 70 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; toluene; 1: |Mitsunobu Displacement / 3: |Sonogashira Cross-Coupling;
DOI:10.1021/ol501125r