1310491-87-2Relevant academic research and scientific papers
Enantioselective Nickel-Catalyzed anti-Arylmetallative Cyclizations onto Acyclic Ketones
Green, Harley,Argent, Stephen P.,Lam, Hon Wai
supporting information, p. 5897 - 5900 (2021/03/16)
Domino reactions involving nickel-catalyzed additions of (hetero)arylboronic acids to alkynes, followed by cyclization of the alkenylnickel intermediates onto tethered acyclic ketones to give chiral tertiary-alcohol-containing products in high enantioselectivities, are described. The reversible E/Z isomerization of the alkenylnickel intermediates enables overall anti-arylmetallative cyclization to occur. The ring system of the products are substructures of certain diarylindolizidine alkaloids.
Gallium(III)-promoted halocyclizations of 1,6-diynes
Strom, Kyle R.,Impastato, Anna C.,Moy, Kenneth J.,Landreth, Adrian J.,Snyder, John K.
supporting information, p. 2126 - 2129 (2015/05/13)
Cyclization of 1,6-diynes promoted by stoichiometric Ga(III) halides produces vinyl halides in good to excellent yields. Under acidic conditions, initially formed iodocyclization products undergo in situ Friedel-Crafts cyclizations, giving access to iodoi
Access to cyclobutene-fused azepines through au-catalyzed cycloisomerization of stable alkyne tethered ketene N,N -acetals
Nayak, Sanatan,Ghosh, Nayan,Sahoo, Akhila K.
, p. 2996 - 2999 (2014/06/23)
A base promoted reaction between N-protected propargyl amines and 3-bromopropiolate readily provides an array of novel stable alkyne-tethered ketene N,N-acetals in good yields. A wide range of structurally complex cyclobutene-fused azepine heterocycles are synthesized through the gold-catalyzed intramolecular cycloisomerization of ketene N,N-acetals for the first time. A plausible reaction pathway is deduced on the basis of the 1H NMR studies.
Carbophilic 3-component cascades: Access to complex bioactive cyclopropyl diindolylmethanes
Groome, Nigel M.,Elboray, Elghareeb E.,Inman, Martyn W.,Dondas, H. Ali,Phillips, Roger M.,Kilner, Colin,Grigg, Ronald
, p. 2180 - 2184 (2013/03/28)
Naturally occurring indole-3-carbinol and 3,3-diindolylmethane show bioactivity in a number of disparate disease areas, including cancer, prompting substantial synthetic analogue activity. We describe a new approach to highly functionalised derivatives that starts from allene gas and proceeds via the combination of a three-component Pd0-catalysed cascade with a one-pot, three-component carbophilic PtII cascade linked to a stereoselective acid-catalysed Mannich-Michael reaction that generates complex cyclopropyl diindolylmethanes which show selective activity against prostate cancer cell lines. Copyright
Au(I)/Au(III)-catalyzed Sonogashira-type reactions of functionalized terminal alkynes with arylboronic acids under mild conditions
Qian, Deyun,Zhang, Junliang
supporting information; experimental part, p. 808 - 812 (2011/08/10)
A straightforward, efficient, and reliable redox catalyst system for the Au(I)/Au(III)-catalyzed Sonogashira cross-coupling reaction of functionalized terminal alkynes with arylboronic acids under mild conditions has been developed.
