N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

Base Information

Chemical Name:N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide
CAS No.:1398110-08-1
Molecular Formula:C₁₉H₁₇Cl₂F₃N₂O₂S
Molecular Weight:465.323
Hs Code.:

Synonyms:N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

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Chemical Property of N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

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Technology Process of N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

There total 7 articles about N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398110-18-3
C-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylthiophen-3-yl}methylamine

: 79-03-8
propionyl chloride

: 1398110-08-1
N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 13679-74-8
2-Acetyl-5-methylthiophen

: 1398110-08-1
N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium acetate; bromine / water / 12 h / 20 °C

2.1: lithium hydride / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere

3.1: triethylamine; trifluoroacetic anhydride / 12 h / 0 - 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 12 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

6.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / Reflux

6.2: 0.5 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

With dimethylsulfide borane complex; hydroxylamine hydrochloride; bromine; sodium acetate; lithium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 36901-17-4
1-(4-bromo-5-methylthiophen-2-yl)ethan-1-one

: 1398110-08-1
N-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3yl]-2-methylthiophen-3-ylmethyl}propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydride / tetrahydrofuran / 5 h / 60 °C / Inert atmosphere

2.1: triethylamine; trifluoroacetic anhydride / 12 h / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 12 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

5.1: dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / Reflux

5.2: 0.5 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

With dimethylsulfide borane complex; hydroxylamine hydrochloride; lithium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;