N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Base Information

Chemical Name:N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester
CAS No.:234081-51-7
Molecular Formula:C₅₂H₉₂N₄O₇
Molecular Weight:885.325
Hs Code.:

<i>N</i>-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-<i>tert</i>-butoxycarbonylamino-succinamic acid benzyl ester

Synonyms:N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Suppliers and Price of N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

There total 3 articles about N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 30925-18-9
2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 229467-49-6
2-amino-N¹,N⁴-dihexadecyl-succinamide

: 234081-51-7
N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Guidance literature:: With dmap; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

: 143-27-1
hexadecylamine

: 234081-51-7
N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 3 h / 20 °C

2: 78 percent / trifluoroacetic acid / CHCl₃ / 2 h / 20 °C

3: 46 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂; dimethylformamide / 5 h / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

: 229467-48-5
(1,2-bis-hexadecylcarbamoyl-ethyl)-carbamic acid tert-butyl ester

: 234081-51-7
N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / trifluoroacetic acid / CHCl₃ / 2 h / 20 °C

2: 46 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂; dimethylformamide / 5 h / 20 °C

With dmap; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(02)00053-1