(-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

Base Information

Chemical Name:(-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene
CAS No.:887250-64-8
Molecular Formula:C₂₀H₁₆F₆FeO₂S
Molecular Weight:490.249
Hs Code.:

Synonyms:(-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

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Chemical Property of (-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

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Technology Process of (-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

There total 1 articles about (-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 130225-27-3,164297-25-0,238753-24-7
(S_S)-ferrocenyl p-tolylsulfoxide

: 684-16-2
Hexafluoroacetone

: 887250-64-8
(-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

Guidance literature:: With lithium diisopropylamide; In tetrahydrofuran; (under Ar or N2, Schlenk); lithium diisopropylamide in THF added to soln. of Fe-complex in THF cooled to -78°C, stirred for 30 min, CO(CF3)2 added, stirred for 1h 15 min, warmed to room temp.; quenched with water, sepd., aq. phase extd. with Et2O, washed with brine, dried over MgSO4, concd. under reduced pressure, silica gel column chromy. with petrol/Et2O; elem. anal.;
DOI:10.1016/j.ica.2005.05.040

Reference yield: 37.0%

: 119-61-9
benzophenone

: 887250-64-8
(-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

: 887250-65-9,887250-62-6
(+)-(Rp)-1-(1-hydroxydiphenylmethyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

Guidance literature:: With NaH; C(CH₃)3Li; In tetrahydrofuran; (under Ar or N2, Schlenk); NaH in mineral oil added to soln. of Fe-complex in THF, stirred for 30 min, cooled to -78°C, C(CH3)3Li added, stirred for 40 min, benzophenone added; quenched with NH4Cl, warmed to room temp., filtered through MgSO4, evapd. to dryness, silica gel column chromy. with petrol/Et2O;
DOI:10.1016/j.ica.2005.05.040

Reference yield:

: 887250-64-8
(-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

: 7789-20-0
water-d2

: [FeCp(η5-C5H3D(C(CF3)2OD))]

: (-)-(Sp,Rc)-1-(toluene-4-sulfinyl)-2-(1-hydroxy-1-hexafluoromethylethyl)ferrocene

Guidance literature:: With C(CH₃)3Li; In water-d2; (under N2 or Ar, Schlenk); Fe-complex treated with C(CH3)3Li at -78°C, after 5 min quenched with D2O; monitored by TLC, NMR;
DOI:10.1016/j.ica.2005.05.040