6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

Base Information

Chemical Name:6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole
CAS No.:142502-28-1
Molecular Formula:C₃₈H₃₇NO₅S
Molecular Weight:619.781
Hs Code.:

Synonyms:6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

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Chemical Property of 6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

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Technology Process of 6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

There total 5 articles about 6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 98-88-4
benzoyl chloride

: 142502-27-0
7α-benzyloxymethyl-6α-hydroxy-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

: 142502-28-1
6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

Guidance literature:: With dmap; triethylamine; In chloroform; for 1h; Heating;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 131938-81-3
(6aR,7S,10aR)-9-Methyl-6-oxo-5-(toluene-4-sulfonyl)-5,6,6a,7,8,10a-hexahydro-indeno[2,1-b]indole-7-carboxylic acid methyl ester

: 142502-28-1
6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / PtO₂/C / tetrahydrofuran / 2 h / 2068.6 Torr

2: 36 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 90 percent / n-Bu₄NHSO₄, 50percent NaOH / benzene / 0.5 h / Ambient temperature

4: 83 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CHCl₃ / 1 h / Heating

With dmap; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; PtO₂/C; In tetrahydrofuran; chloroform; benzene;
DOI:10.1016/0223-5234(92)90100-F

Reference yield:

: 100-39-0
benzyl bromide

: 142502-28-1
6α-benzoyloxy-7α-benzyloxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / n-Bu₄NHSO₄, 50percent NaOH / benzene / 0.5 h / Ambient temperature

2: 83 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CHCl₃ / 1 h / Heating

With dmap; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; In chloroform; benzene;
DOI:10.1016/0223-5234(92)90100-F