(+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Base Information

Chemical Name:(+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide
CAS No.:279690-45-8
Molecular Formula:C₁₇H₃₄OSi
Molecular Weight:282.542
Hs Code.:

Synonyms:(+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Suppliers and Price of (+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

There total 4 articles about (+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 279690-44-7
(-)-(2S,4R)-2-(tert-butyldimethylsilyloxy)methyl-3,3,4-trimethylcyclohexan-1-one

: 74-95-3
1,1-dibromomethane

: 279690-45-8
(+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Guidance literature:: With titanium tetrachloride; zinc; In dichloromethane; at 5 ℃; for 4h;
DOI:10.1021/jo991903h

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 279690-45-8
(+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / imidazole / dimethylformamide / 3 h / 20 °C

2: 91 percent / Zn dust; TiCl₄ / CH₂Cl₂ / 4 h / 5 °C

With 1H-imidazole; titanium tetrachloride; zinc; In dichloromethane; N,N-dimethyl-formamide; 1: silylation / 2: methylenation;
DOI:10.1021/jo991903h

Reference yield:

: methyl (3R)-2,2,3-trimethyl-6-oxo-cyclohexanecarboxylate

: 279690-45-8
(+)-[(1S,3R)-2,3,3-trimethyl-6-methylidenecyclohexyl]methyl-tert-butyldimethylsilyl oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

1.2: AlH₃ / tetrahydrofuran / 1 h / -10 °C

1.3: 4 percent / t-BuOH / diethyl ether / 3 h / -85 - -20 °C

2.1: 87 percent / imidazole / dimethylformamide / 3 h / 20 °C

3.1: 91 percent / Zn dust; TiCl₄ / CH₂Cl₂ / 4 h / 5 °C

With 1H-imidazole; titanium tetrachloride; sodium hydride; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Metallation / 1.3: protonation / 2.1: silylation / 3.1: methylenation;
DOI:10.1021/jo991903h