NS-018

Base Information

Chemical Name:NS-018
CAS No.:1239358-86-1
Molecular Formula:C₂₁H₂₀FN₇
Molecular Weight:389.435
Hs Code.:
Mol file:1239358-86-1.mol

Synonyms:N₂-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N₆-(pyrazin-2-yl)pyridine-2,6-diamine

Suppliers and Price of NS-018

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
NS-018 >98%
100 mg
$ 700.00

DC Chemicals
NS-018 >98%
250 mg
$ 1400.00

DC Chemicals
NS-018 >98%
1 g
$ 2800.00

Crysdot
NS-018 98+%
100mg
$ 1459.00

Crysdot
NS-018 98+%
5mg
$ 243.00

Crysdot
NS-018 98+%
50mg
$ 1042.00

Crysdot
NS-018 98+%
10mg
$ 347.00

ChemScene
Ilginatinib 99.15%
25mg
$ 580.00

ChemScene
Ilginatinib 99.15%
10mg
$ 395.00

ChemScene
Ilginatinib 99.15%
5mg
$ 285.00

Total 6 raw suppliers

Chemical Property of NS-018

Chemical Property:

Boiling Point:574.1±50.0 °C(Predicted)
PKA:2.43±0.10(Predicted)
Density:1.31±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

NS-018 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of NS-018

There total 3 articles about NS-018 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5049-61-6
2-Aminopyrazine

: 1239362-91-4
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

: 1239358-86-1
N₂-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N₆-(pyrazin-2-yl)pyridine-2,6-diamine

Guidance literature:: With sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 100 ℃; for 1.5h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 1239358-86-1
N₂-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N₆-(pyrazin-2-yl)pyridine-2,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

2: sodium t-butanolate; johnphos; palladium diacetate / toluene / 2 h / 85 °C / Inert atmosphere

3: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 1.5 h / 89 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; johnphos; sodium t-butanolate; XPhos; In 1,4-dioxane; water; toluene;

Reference yield:

: 1239362-90-3
2,6-dichloro-4-(1-methyl-1H-pyrazol-4-yl)pyridine

: 1239358-86-1
N₂-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N₆-(pyrazin-2-yl)pyridine-2,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; johnphos; palladium diacetate / toluene / 2 h / 85 °C / Inert atmosphere

2: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 1.5 h / 89 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; johnphos; sodium t-butanolate; XPhos; In toluene;