Technology Process of 8-(bromomethyl)-3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide
There total 18 articles about 8-(bromomethyl)-3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole; bromine; triphenylphosphine;
In
dichloromethane;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 65 °C
1.2: 2 h / 0 °C
2.1: chlorosulfonic acid / ethyl acetate / 3 h / 25 - 40 °C
3.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux
3.2: 15 h / 85 °C
4.1: citric acid / toluene / 50 h / 130 °C / Reflux
5.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C
6.2: 0.5 h
7.1: borane-THF / tetrahydrofuran / 2 h / 25 °C
8.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C
8.2: 1 h / pH 12 / Cooling with ice
9.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C
With
1H-imidazole; chlorosulfonic acid; lithium aluminium tetrahydride; borane-THF; 1,3-bis-(diphenylphosphino)propane; dihydrogen peroxide; bromine; triethylamine; triphenylphosphine; trifluoroacetic acid; citric acid; potassium hydroxide;
palladium diacetate;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: trifluorormethanesulfonic acid / dichloromethane / 49 h / 5 - 20 °C / Reflux
2.1: boron trichloride / dichloromethane / 0.5 h / 0 - 5 °C
2.2: 0.5 h / 10 °C
2.3: 0.5 h / 15 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C
3.2: 3 h / 60 °C
4.1: diphenylether / 4.5 h / 215 °C
5.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux
5.2: 15 h / 85 °C
6.1: citric acid / toluene / 50 h / 130 °C / Reflux
7.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C
8.2: 0.5 h
9.1: borane-THF / tetrahydrofuran / 2 h / 25 °C
10.1: trifluoroacetic acid; dihydrogen peroxide / water / 1 h / 25 °C
10.2: 1 h / pH 12 / Cooling with ice
11.1: 1H-imidazole; triphenylphosphine; bromine / dichloromethane / 2 h / 0 °C
With
1H-imidazole; lithium aluminium tetrahydride; borane-THF; trifluorormethanesulfonic acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; dihydrogen peroxide; bromine; boron trichloride; triethylamine; triphenylphosphine; trifluoroacetic acid; citric acid; potassium hydroxide;
palladium diacetate;
In
tetrahydrofuran; diphenylether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
![[3,3-dibutyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol](/Databaselist/images/loading.webp)
