(1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester
• CAS No.: 116910-18-0
• Molecular Formula: C₁₃H₁₄O₃
• Molecular Weight: 218.252
• Mol file: 116910-18-0.mol

Synonyms:(1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester

Chemical Property of (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester

There total 6 articles about (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(1aR,1bR,4S,5aS)-4-Isopropyl-1b-methyl-5a-phenyl-hexahydro-2-oxa-4a-aza-cyclopropa[a]pentalen-5-one (116910-16-8) → (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester (116910-18-0)

Guidance literature:

With sulfuric acid; In methanol; for 96h; Heating;

DOI:10.1021/ja00229a067

Reference yield: 81.0%

methanol (67-56-1) + (1aR,1bR,4S,5aS)-4-Isopropyl-1b-methyl-5a-phenyl-hexahydro-2-oxa-4a-aza-cyclopropa[a]pentalen-5-one (116910-16-8) → (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester (116910-18-0)

Guidance literature:

With sulfuric acid; for 96h; Heating;

DOI:10.1016/S0040-4020(01)85604-0

Reference yield:

(3S,7aR)-3-Isopropyl-7a-methyl-6-phenyl-2,3-dihydro-7aH-pyrrolo[2,1-b]oxazol-5-one (116910-13-5) → (1S,2R)-2-Acetyl-1-phenyl-cyclopropanecarboxylic acid methyl ester (116910-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent

2: 81 percent / 10percent H₂SO₄ / methanol / 96 h / Heating

With sulfuric acid; In methanol;

DOI:10.1021/ja00229a067

upstream raw materials:

methanol

(1aR,1bR,4S,5aS)-4-Isopropyl-1b-methyl-5a-phenyl-hexahydro-2-oxa-4a-aza-cyclopropa[a]pentalen-5-one

(3S,7aR)-3-Isopropyl-7a-methyl-6-phenyl-2,3-dihydro-7aH-pyrrolo[2,1-b]oxazol-5-one

(E)-Methyl 4-oxo-2-phenyl-2-pentenoate