methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

Base Information

Chemical Name:methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate
CAS No.:642487-00-1
Molecular Formula:C₄₇H₅₄O₇
Molecular Weight:730.942
Hs Code.:

Synonyms:methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

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Chemical Property of methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

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Technology Process of methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

There total 4 articles about methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 642486-99-5
methyl 4-(2,6-bis-{2-[2,5-dipropyloxy-4-(2-triisopropylsilylethynyl)phenyl]-ethynyl}-4-tert-butylphenoxy)-butyrate

: 642487-00-1
methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2003.09.045

Reference yield:

: 55444-67-2
trimethyl ortho-4-bromobutanoate

: 642487-00-1
methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / K₂CO₃; KI / dimethylformamide / 20 h / 60 °C

2: 94 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 19 h / 20 - 50 °C

3: 84 percent / Bu₄NF / tetrahydrofuran; H₂O / 2 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Hagihara-Sonogashira coupling;
DOI:10.1016/j.tet.2003.09.045

Reference yield:

: 75908-75-7
2,6-diiodo-4-(tert-butyl)phenol

: 642487-00-1
methyl 4-{2,6-bis-[2-(2,5-dipropyloxy-4-ethynylphenyl)-ethynyl]-4-tert-butylphenoxy}-butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / K₂CO₃; KI / dimethylformamide / 20 h / 60 °C

2: 94 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 19 h / 20 - 50 °C

3: 84 percent / Bu₄NF / tetrahydrofuran; H₂O / 2 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Hagihara-Sonogashira coupling;
DOI:10.1016/j.tet.2003.09.045