2'-triethylsilyl-7-methylthiomethylpaclitaxel

Base Information

• Chemical Name: 2'-triethylsilyl-7-methylthiomethylpaclitaxel
• CAS No.: 174674-03-4
• Molecular Formula: C₅₅H₆₉NO₁₄SSi
• Molecular Weight: 1028.3
• Mol file: 174674-03-4.mol

Synonyms:2'-triethylsilyl-7-methylthiomethylpaclitaxel

Chemical Property of 2'-triethylsilyl-7-methylthiomethylpaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-triethylsilyl-7-methylthiomethylpaclitaxel

There total 2 articles about 2'-triethylsilyl-7-methylthiomethylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethylsulfide (75-18-3) + (2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate (148930-54-5) → 2'-triethylsilyl-7-methylthiomethylpaclitaxel (174674-03-4)

Guidance literature:

With dibenzoyl peroxide; In acetonitrile;

DOI:10.1016/S0960-894X(01)00067-1

Reference yield:

taxol (33069-62-4) → 2'-triethylsilyl-7-methylthiomethylpaclitaxel (174674-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / pyridine; ' / CH₂Cl₂ / 1 h / 0 °C

2: 95 percent / benzoyl peroxide / acetonitrile / 1.5 h

With pyridine; dibenzoyl peroxide; In dichloromethane; acetonitrile;

DOI:10.1021/jm0102607

Reference yield: 95.0%

2'-triethylsilyl-7-methylthiomethylpaclitaxel (174674-03-4) → BMS-184476 (160237-25-2)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 0 ℃; for 1h;

DOI:10.1021/jm0102607

upstream raw materials:

dimethylsulfide

(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

taxol

Downstream raw materials:

C₅₆H₆₈ClNO₁₆Si

C₆₈H₈₄Cl₂N₂O₁₆Si

BMS-184476

7-methylthiomethyl baccatin III