160237-25-2Relevant academic research and scientific papers
Synthesis and antitumor activity of novel C-7 paclitaxel ethers: Discovery of BMS-184476
Altstadt,Fairchild,Golik,Johnston,Kadow,Lee,Long,Rose,Vyas,Wong,Wu,Wittman
, p. 4577 - 4583 (2007/10/03)
The preparation of C-7 paclitaxel ethers is described. Various substituted ethers were prepared via activation of the corresponding methylthiomethyl ether followed by alcohol addition. Variation of the C-7 ether group as well the 3′ side chain position le
Synthesis and antitumor evaluation of paclitaxel phosphonooxymethyl ethers: A novel class of water soluble paclitaxel pro-drugs
Golik, Jerzy,Wong, Henry S. L.,Chen, Shu Hui,Doyle, Terrence W.,Wright, J. J. Kim,Knipe, Jay,Rose, William C.,Casazza, Anna Maria,Vyas, Dolatrai. M.
, p. 1837 - 1842 (2007/10/03)
The synthesis, pharmacokinetic properties, and antitumor evaluation of novel paclitaxel phosphonooxymethyl ether derivatives 8-11 and salts thereof is described. These compounds exhibit improved water solubility as compared to paclitaxel (1) and upon incubation with plasma and alkaline phosphatase they readily release parent drug. The in vivo antitumor evaluation of compounds 8-11 established them as suitable pro-drugs of paclitaxel.
