1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

Base Information

Chemical Name:1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea
CAS No.:455312-14-8
Molecular Formula:C₂₆H₂₄N₆O₇
Molecular Weight:532.513
Hs Code.:

1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1<i>H</i>-4,8a-diaza-<i>as</i>-indacen-3-yl]-urea

Synonyms:1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

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Chemical Property of 1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

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Technology Process of 1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

There total 15 articles about 1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 455312-13-7
1H-Pyrrole-2-carboxylic acid [(1S,2S,3R,5S)-3-hydroxy-2-[3-methyl-3-(2-nitro-benzyl)-ureido]-5-(toluene-4-sulfonyl)-cyclopentyl]-(2-nitro-benzyl)-amide

: 455312-14-8
1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide;
DOI:10.1021/ja027121e

Reference yield:

: 5427-82-7
1H-pyrrole-2-carbonyl chloride

: 455312-14-8
1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; 4-(dimethylamino)pyridine / 1,2-dichloro-ethane / 48 h / 30 - 55 °C

2.1: Cs₂CO₃ / methanol / 18 h / 20 °C

3.1: dimethyl sulfoxide; oxalyl chloride / CH₂Cl₂ / 0.22 h / -78 - 20 °C

3.2: Et₃N / CH₂Cl₂ / -78 - 20 °C

With pyridine; dmap; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; In methanol; dichloromethane; 1,2-dichloro-ethane; 3.1: Swern oxidation;
DOI:10.1021/jo026287v

Reference yield:

: 455312-09-1
(3aS,6aR)-2-Oxo-5-(toluene-4-sulfonyl)-6,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid methyl-(2-nitro-benzyl)-amide

: 455312-14-8
1-methyl-1-(2-nitro-benzyl)-3-[4-(2-nitro-benzyl)-2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl]-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 120 h / Heating

2.1: pyridine; 4-(dimethylamino)pyridine / 1,2-dichloro-ethane / 48 h / 30 - 55 °C

3.1: Cs₂CO₃ / methanol / 18 h / 20 °C

4.1: dimethyl sulfoxide; oxalyl chloride / CH₂Cl₂ / 0.22 h / -78 - 20 °C

4.2: Et₃N / CH₂Cl₂ / -78 - 20 °C

With pyridine; dmap; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; 4.1: Swern oxidation;
DOI:10.1021/jo026287v