4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

Base Information

Chemical Name:4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide
CAS No.:1421592-17-7
Molecular Formula:C₁₇H₁₅N₃O₄S
Molecular Weight:357.39
Hs Code.:

Synonyms:4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

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Chemical Property of 4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

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Technology Process of 4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

There total 5 articles about 4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 105743-62-2
4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

: 100-52-7
benzaldehyde

: 1421592-17-7
4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; diastereoselective reaction;
DOI:10.3390/molecules171214126

Reference yield:

: 24683-26-9
ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

: 1421592-17-7
4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; hydrazine hydrate; In ethanol; water;
DOI:10.3390/molecules171214126

Reference yield:

: 128-44-9
saccharin sodium salt

: 1421592-17-7
4-hydroxy-2-methyl-N'-[(E)-phenylmethylidene]-2H-1,2-benzothiazine-3-carbohydrazide-1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 3 h / 120 °C

2: sodium ethanolate / ethanol / 2 h / Inert atmosphere; Reflux

3: sodium ethanolate / N,N-dimethyl-formamide / 20 °C

4: hydrazine hydrate / water / 20 °C

5: sulfuric acid / ethanol / 2 h / Reflux

With sulfuric acid; sodium ethanolate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide; 2: |Gabriel-Colman Rearrangement;
DOI:10.2174/1573406417666210125141639