ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Base Information

Chemical Name:ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate
CAS No.:1607830-85-2
Molecular Formula:C₁₆H₁₂F₃N₃O₂
Molecular Weight:335.285
Hs Code.:

Synonyms:ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

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Chemical Property of ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

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Technology Process of ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

There total 6 articles about ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1607829-61-7
ethyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1607830-85-2
ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Guidance literature:: With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; at 110 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/ml500244m

Reference yield:

: 67-56-1
methanol

: 1607829-61-7
ethyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1607830-85-2
ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

: 1607830-53-4
methyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Guidance literature:: With potassium fluoride; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; toluene; at 110 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 588720-67-6
ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate

: 1607830-85-2
ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

2: tris-(o-tolyl)phosphine; potassium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; toluene / 0.2 h / 110 °C / Microwave irradiation

With potassium fluoride; N-Bromosuccinimide; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; water; toluene; 2: |Suzuki Coupling;