2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

Base Information

Chemical Name:2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate
CAS No.:635751-42-7
Molecular Formula:C₂₈H₃₃F₃N₄O₆S
Molecular Weight:610.654
Hs Code.:

Synonyms:2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

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Chemical Property of 2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

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Technology Process of 2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

There total 6 articles about 2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₂₀ClNO₄

: 138530-94-6
(R)-lansoprazole

: 635751-42-7
2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

Guidance literature:: With triethylamine; dmap; In tetrahydrofuran; at 60 ℃; for 24h;

Reference yield:

: 635750-93-5
2-(cyclohexylamino)ethyl ethyl carbonate hydrochloride

: 32315-10-9
bis(trichloromethyl) carbonate

: 138530-94-6
(R)-lansoprazole

: 635751-42-7
2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

Guidance literature:: 2-(cyclohexylamino)ethyl ethyl carbonate hydrochloride; bis(trichloromethyl) carbonate; With pyridine; triethylamine; In tetrahydrofuran; at 20 ℃; for 2.5h; Ice-cooling;

(R)-lansoprazole; With triethylamine; dmap; In tetrahydrofuran; at 60 ℃; for 24h;

Reference yield:

: 2842-38-8
cyclohexyl(2-(hydroxy)ethyl)amine

: 635751-42-7
2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 48 h / 20 °C

2.1: dmap; pyridine / tetrahydrofuran / 15 h / 20 °C / Cooling with ice

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: pyridine / tetrahydrofuran / 0.5 h / Cooling with ice

4.2: 2 h / 20 °C

5.1: dmap; triethylamine / tetrahydrofuran / 24 h / 60 °C

With pyridine; hydrogenchloride; dmap; triethylamine; In tetrahydrofuran; ethanol; ethyl acetate;