Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

Base Information

Chemical Name:Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate
CAS No.:89321-01-7
Molecular Formula:C₄₅H₅₂ClF₅N₄O₉
Molecular Weight:923.374
Hs Code.:

Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

Synonyms:Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

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Chemical Property of Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

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Technology Process of Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

There total 17 articles about Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89278-31-9
Methyl 10-Benzyloxy-2-(S)-benzyloxycarbonylamino-8(S),9(S)-O-isopropylidene-2(E/Z),6(E/Z)-decadienoate

: 89321-01-7
Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / +BF₄- / ethanol / 72 h / 2250.2 Torr / Ambient temperature

2: H₂ / Pd / methanol / 24 h / 2250.2 Torr / Ambient temperature

4: 1-chlor-1-dimethylamino-2-methyl-1-propen, pyridine / CH₂Cl₂ / 1.) -20 deg C, 30 min 2.) 40 deg C, 30 min

5: NaOH pH<11 / H₂O; dioxane / 5 h / Ambient temperature

6: DCCD / ethyl acetate / -20 deg C to RT

7: NaOH / H₂O; dioxane / 5 h / Ambient temperature

8: DCCD / ethyl acetate / -20 deg C to RT

With pyridine; sodium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrogen; dicyclohexyl-carbodiimide; (R,R)-(-)-1,2-bis[(o-methoxyphenyl)(phenyl) phosphino]ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; palladium; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 89278-34-2
8-Benzyloxy-6(S),7(S)-O-isopropylidene-1-octanal

: 89321-01-7
Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

Guidance literature:: Multi-step reaction with 9 steps

1: KO-tBu / CH₂Cl₂ / 0.5 h / -70 °C

2: H₂ / +BF₄- / ethanol / 72 h / 2250.2 Torr / Ambient temperature

3: H₂ / Pd / methanol / 24 h / 2250.2 Torr / Ambient temperature

5: 1-chlor-1-dimethylamino-2-methyl-1-propen, pyridine / CH₂Cl₂ / 1.) -20 deg C, 30 min 2.) 40 deg C, 30 min

6: NaOH pH<11 / H₂O; dioxane / 5 h / Ambient temperature

7: DCCD / ethyl acetate / -20 deg C to RT

8: NaOH / H₂O; dioxane / 5 h / Ambient temperature

9: DCCD / ethyl acetate / -20 deg C to RT

With pyridine; sodium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium tert-butylate; hydrogen; dicyclohexyl-carbodiimide; (R,R)-(-)-1,2-bis[(o-methoxyphenyl)(phenyl) phosphino]ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; palladium; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 78513-04-9
(4S,5S)-p-toluolsulfonsaeure<(5-benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl>ester

: 89321-01-7
Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate

Guidance literature:: Multi-step reaction with 10 steps

2: KO-tBu / CH₂Cl₂ / 0.5 h / -70 °C

3: H₂ / +BF₄- / ethanol / 72 h / 2250.2 Torr / Ambient temperature

4: H₂ / Pd / methanol / 24 h / 2250.2 Torr / Ambient temperature

6: 1-chlor-1-dimethylamino-2-methyl-1-propen, pyridine / CH₂Cl₂ / 1.) -20 deg C, 30 min 2.) 40 deg C, 30 min

7: NaOH pH<11 / H₂O; dioxane / 5 h / Ambient temperature

8: DCCD / ethyl acetate / -20 deg C to RT

9: NaOH / H₂O; dioxane / 5 h / Ambient temperature

10: DCCD / ethyl acetate / -20 deg C to RT

With pyridine; sodium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium tert-butylate; hydrogen; dicyclohexyl-carbodiimide; (R,R)-(-)-1,2-bis[(o-methoxyphenyl)(phenyl) phosphino]ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; palladium; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;