3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

Base Information

Chemical Name:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)
CAS No.:1347656-18-1
Molecular Formula:C₂₆H₂₄F₅N₅O₃S
Molecular Weight:581.566
Hs Code.:

Synonyms:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

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Chemical Property of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

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Technology Process of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

There total 9 articles about 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347656-15-8
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

: 75-36-5
acetyl chloride

: 1347656-18-1
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

Guidance literature:: 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime; acetyl chloride; With triethylamine; In dichloromethane; for 2h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 1003320-13-5
1-(2-chloroacetyl)-N-(1,1-dimethylethyl)-4-piperidinecarboxamide

: 1347656-18-1
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 1.5 h / 37 - 55 °C

1.2: 10 °C / pH 5.5

2.1: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

3.1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

4.1: methanol / 20 °C

5.1: aluminum oxide / dichloromethane / 20 h / Reflux

6.1: hydroxylamine hydrochloride / methanol / 2 h / Reflux

7.1: triethylamine / dichloromethane / 2 h

With aluminum oxide; hydrogen sulfide; hydroxylamine hydrochloride; triethylamine; 2,2'-iminobis[ethanol]; potassium hydroxide; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinecarbonitrile

: 1347656-18-1
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-(O-acetyloxime)

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

2: methanol / 20 °C

3: aluminum oxide / dichloromethane / 20 h / Reflux

4: hydroxylamine hydrochloride / methanol / 2 h / Reflux

5: triethylamine / dichloromethane / 2 h

With aluminum oxide; hydrogen sulfide; hydroxylamine hydrochloride; triethylamine; 2,2'-iminobis[ethanol]; In methanol; dichloromethane; N,N-dimethyl-formamide;