3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

Base Information

Chemical Name:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime
CAS No.:1347656-15-8
Molecular Formula:C₂₄H₂₂F₅N₅O₂S
Molecular Weight:539.529
Hs Code.:

Synonyms:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

There total 8 articles about 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347656-60-3
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

: 1347656-15-8
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

Guidance literature:: With hydroxylamine hydrochloride; In methanol; for 2h; Reflux;

Reference yield:

: 1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinecarbonitrile

: 1347656-15-8
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

2: methanol / 20 °C

3: aluminum oxide / dichloromethane / 20 h / Reflux

4: hydroxylamine hydrochloride / methanol / 2 h / Reflux

With aluminum oxide; hydrogen sulfide; hydroxylamine hydrochloride; 2,2'-iminobis[ethanol]; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4395-98-6
4-cyanopiperidine

: 1347656-15-8
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one 1-oxime

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / dichloromethane; water / 1.25 h / -10 - 0 °C

2: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

3: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

4: methanol / 20 °C

5: aluminum oxide / dichloromethane / 20 h / Reflux

6: hydroxylamine hydrochloride / methanol / 2 h / Reflux

With aluminum oxide; hydrogen sulfide; hydroxylamine hydrochloride; potassium carbonate; 2,2'-iminobis[ethanol]; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;