2-benzyloxy-5-chlorophenyl formate

Base Information

• Chemical Name: 2-benzyloxy-5-chlorophenyl formate
• CAS No.: 1189360-81-3
• Molecular Formula: C₁₄H₁₁ClO₃
• Molecular Weight: 262.693
• Mol file: 1189360-81-3.mol

Synonyms:2-benzyloxy-5-chlorophenyl formate

Chemical Property of 2-benzyloxy-5-chlorophenyl formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-benzyloxy-5-chlorophenyl formate

There total 1 articles about 2-benzyloxy-5-chlorophenyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2-(benzyloxy)-5-chlorobenzaldehyde (38544-16-0) → 2-benzyloxy-5-chlorophenyl formate (1189360-81-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 2h; Reflux;

DOI:10.1016/j.ejmech.2014.09.100

Reference yield: 97.1%

2-benzyloxy-5-chlorophenyl formate (1189360-81-3) → 2-benzyloxy-5-chlorophenol (1189360-82-4)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2014.09.100

Reference yield:

2-benzyloxy-5-chlorophenyl formate (1189360-81-3) → 3-(5-chloro-2-hydroxyphenoxy)-1,2-epoxypropane (1229827-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 40 °C

3.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 20 °C

With 5%-palladium/activated carbon; hydrogen; potassium carbonate; sodium hydroxide; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.09.100

upstream raw materials:

2-(benzyloxy)-5-chlorobenzaldehyde

Downstream raw materials:

2-benzyloxy-5-chlorophenol

3-(2-benzyloxy-5-chlorophenoxy)-1,2-epoxypropane

3-(5-chloro-2-hydroxyphenoxy)-1,2-epoxypropane