2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

Base Information

Chemical Name:2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine
CAS No.:107610-28-6
Molecular Formula:C₁₆H₁₆N₂O₇
Molecular Weight:348.312
Hs Code.:

Synonyms:2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

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Chemical Property of 2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

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Technology Process of 2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

There total 3 articles about 2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 126397-26-0
2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester

: 107610-28-6
2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

Guidance literature:: With triethylamine; In methanol; for 16h; Heating;
DOI:10.1248/cpb.37.2117

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 107610-28-6
2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 28percent NH₄OH, / methanol; H₂O / 16 h / Heating

2: 285 mg / methanol / 4.5 h / Heating

3: 95 percent / Et₃N, / methanol / 16 h / Heating

With ammonium hydroxide; triethylamine; In methanol; water;
DOI:10.1248/cpb.37.2117

Reference yield:

: 14205-39-1
methyl 3-aminocrotonate

: 107610-28-6
2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 285 mg / methanol / 4.5 h / Heating

2: 95 percent / Et₃N, / methanol / 16 h / Heating

With triethylamine; In methanol;
DOI:10.1248/cpb.37.2117