2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester

Base Information

• Chemical Name: 2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester
• CAS No.: 126397-26-0
• Molecular Formula: C₁₇H₂₀N₂O₈
• Molecular Weight: 380.354

Synonyms:2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester

Chemical Property of 2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester

Chemical Property:

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Technology Process of 2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester

There total 2 articles about 2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetoacetic acid methyl ester (105-45-3) → 2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester (126397-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 28percent NH₄OH, / methanol; H₂O / 16 h / Heating

2: 285 mg / methanol / 4.5 h / Heating

With ammonium hydroxide; In methanol; water;

DOI:10.1248/cpb.37.2117

Reference yield:

dimethyl (3-nitrobenzylidene)malonate (74313-93-2) + methyl 3-aminocrotonate (14205-39-1) → 2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester (126397-26-0)

Guidance literature:

In methanol; for 4.5h; Heating;

DOI:10.1248/cpb.37.2117

Reference yield: 95.0%

2-[1-Amino-eth-(E)-ylidene]-4-methoxycarbonyl-3-(3-nitro-phenyl)-pentanedioic acid dimethyl ester (126397-26-0) → 2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine (107610-28-6)

Guidance literature:

With triethylamine; In methanol; for 16h; Heating;

DOI:10.1248/cpb.37.2117

upstream raw materials:

dimethyl (3-nitrobenzylidene)malonate

methyl 3-aminocrotonate

acetoacetic acid methyl ester

Downstream raw materials:

2-hydroxy-3,5-bis(methoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

2-Chloro-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

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