4-bromo-2-chloro-N-cyclopropylaniline

Base Information

• Chemical Name: 4-bromo-2-chloro-N-cyclopropylaniline
• CAS No.: 1152617-42-9
• Molecular Formula: C₉H₉BrClN
• Molecular Weight: 246.534
• Mol file: 1152617-42-9.mol

Synonyms:4-bromo-2-chloro-N-cyclopropylaniline

Chemical Property of 4-bromo-2-chloro-N-cyclopropylaniline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-bromo-2-chloro-N-cyclopropylaniline

There total 2 articles about 4-bromo-2-chloro-N-cyclopropylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

[(1-Ethoxycyclopropyl)oxy]trimethylsilane (27374-25-0) + 2-chloro-4-bromoaniline (38762-41-3) → 4-bromo-2-chloro-N-cyclopropylaniline (1152617-42-9)

Guidance literature:

[(1-Ethoxycyclopropyl)oxy]trimethylsilane; 2-chloro-4-bromoaniline; In methanol; acetic acid; at 70 ℃; for 4h;

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 70 ℃;

Reference yield:

C11H13BrClNO (1152618-10-4) → 4-bromo-2-chloro-N-cyclopropylaniline (1152617-42-9)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 5 - 20 ℃; for 7.33h; Heating / reflux;

Reference yield: 78.0%

4-bromo-2-chloro-N-cyclopropylaniline (1152617-42-9) + methyl iodide (74-88-4) → C10H11BrClN (1426320-92-4)

Guidance literature:

4-bromo-2-chloro-N-cyclopropylaniline; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

upstream raw materials:

C₁₁H₁₃BrClNO

[(1-Ethoxycyclopropyl)oxy]trimethylsilane

2-chloro-4-bromoaniline

Downstream raw materials:

[2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropyl-amine

C₁₀H₁₁BrClN