N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Base Information

• Chemical Name: N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine
• CAS No.: 1377585-37-9
• Molecular Formula: C₁₅H₁₅NO₃S
• Molecular Weight: 289.355
• Mol file: 1377585-37-9.mol

Synonyms:N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Chemical Property of N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine

There total 5 articles about N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-methyl-N-(methyl(oxo)(phenyl)-λ6-sulfanylidene)benzamide (1377585-41-5) → N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-37-9)

Guidance literature:

With oxygen; palladium diacetate; butyraldehyde; In 1,2-dichloro-ethane; at 80 ℃; for 24h;

DOI:10.1002/cctc.201800064

Reference yield: 65.0%

3-methyl-N-(methyl(oxo)(phenyl)-λ6-sulfanylidene)benzamide (1377585-41-5) + acetic acid (64-19-7,77671-22-8) → N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-37-9) + N-[2-acetoxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-09-5) + N-[2,6-diacetoxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-31-3)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; In chloroform; at 100 ℃; for 48h; air;

DOI:10.1002/chem.201200092

Reference yield:

methyl-phenyl-thioether (100-68-5) → N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-37-9) + N-[2-acetoxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-09-5) + N-[2,6-diacetoxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine (1377585-31-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dihydrogen peroxide / water / 40 °C

2.1: sodium azide; sulfuric acid / chloroform / Inert atmosphere

2.2: 12 h / 0 - 45 °C

3.1: sodium hydride / dichloromethane; mineral oil / 20 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: dipotassium peroxodisulfate; palladium diacetate / chloroform / 48 h / 100 °C / air

With dipotassium peroxodisulfate; sodium azide; sulfuric acid; dihydrogen peroxide; palladium diacetate; sodium hydride; In dichloromethane; chloroform; water; mineral oil;

DOI:10.1002/chem.201200092

upstream raw materials:

3-methyl-N-(methyl(oxo)(phenyl)-λ⁶-sulfanylidene)benzamide

acetic acid

methyl-phenyl-thioether

racemic methyl phenyl sulfoxide